Reviews

Stem cell-derived gametes: what to expect when expecting their clinical introduction

Ilse J de Bruin, Merel M Spaander, Simone Harmsen, Rosanne Edelenbosch, M Corrette Ploem, Nina Dartée, Madalena Cardoso Vaz Santos, Mathangi Lakshmipathi, Callista L Mulder, Ans M M van Pelt, Willy M Baarends, Susana M Chuva de Sousa Lopes, Guido M W R de Wert, Seppe Segers, Geert Hamer, Ana M Pereira Daoud, on behalf of the HipGametes Consortium, Stem cell-derived gametes: what to expect when expecting their clinical introduction, Human Reproduction, 2025; deaf123.

Global Literature Analysis of Organoid and Organ-on-Chip Research.

J. Shoji, R. P. Davis, C. L. Mummery, S. Krauss, Global Literature Analysis of Organoid and Organ-on-Chip Research. Adv. Healthcare Mater. 2024, 13, 2301067.

Haematopoietic development and HSC formation in vitro: promise and limitations of gastruloid models.

Liza Dijkhuis, Ayona Johns, Denise Ragusa, Susanne C. van den Brink, Cristina Pina; Haematopoietic development and HSC formation in vitro: promise and limitations of gastruloid models. Emerg Top Life Sci 18 December 2023; 7 (4): 439–454.

Three-dimensional cardiac models: a pre-clinical testing platform.

Groen E, Mummery CL, Yiangou L, Davis RP. Three-dimensional cardiac models: a pre-clinical testing platform. Biochem Soc Trans. 2024 Jun 26;52(3):1045-1059. doi: 10.1042/BST20230444. PMID: 38778769; PMCID: PMC11346450.

Retrospective analysis of enhancer activity and transcriptome history.

Boers R, Boers J, Tan B, van Leeuwen ME, Wassenaar E, Sanchez EG, Sleddens E, Tenhagen Y, Mulugeta E, Laven J, Creyghton M, Baarends W, van IJcken WFJ, Gribnau J. Retrospective analysis of enhancer activity and transcriptome history. Nat Biotechnol. 2023 Feb 23.

Bioengineering in vitro models of embryonic development

Ananya Gupta, Matthias P. Lutolf*, Alex J. Hughes* and Katharina F. Sonnen*: Bioengineering in vitro models of embryonic development. Stem Cell Reports 16 (2021)

Lees meer

Development in a dish – in vitro models of mammalian embryonic development

Yasmine el Azhar and Katharina F. Sonnen*: Development in a dish – in vitro models of mammalian embryonic development. Frontiers in Cell and Developmental Biology (2021)

Microfluidics as an emerging precision tool in developmental biology

Katharina F. Sonnen and Christoph A. Merten*: Microfluidics as an emerging precision tool in developmental biology. Developmental Cell, 48 (2019)

How germline genes promote malignancy in cancer cells

Jan Willem Bruggeman, Jan Koster, Ans M. M. van Pelt, Dave Speijer and Geert Hamer: How germline genes promote malignancy in cancer cells. BioEssays (2023)

Molecular makeup of the human adult ovary

Xueying Fan and Susana M. Chuva de Sousa Lopes: Molecular makeup of the human adult ovary. Current Opinion in Endocrine and Metabolic Research (2021)

Fetal germ cell development in humans, a link with infertility

Sylwia M. Czukiewska and Susana M. Chuva de Sousa Lopes: Fetal germ cell development in humans, a link with infertility. Seminars in Cell & Developmental Biology (2022)

Contribute to the consortium

Developments in medical technology can raise moral dilemmas. This also applies to stem cell research and specifically to the development of embryo models. Ethical, legal and social issues (ELSI), also known as Socially Responsible Innovation (MVI), are therefore a strong point of attention within the program.

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Events

Join us at the Dutch Embryo Model Meeting 2024!

The Dutch Embryo Model Meeting presents a valuable opportunity for scientists involved in research with stem-cell-based embryo models to showcase their work, and many of the researchers involved in our program eagerly anticipate presenting their research findings at this event.

HipGametes

Report: Seeds for a Societal Debate

The recent report of the Rathenau Institute, entitled 'Seeds for a Societal Debate', is now online!

Embryo models from the lab: what can you do with them?

In the Netherlands, about two thousand people live with the muscle disease FSHD. With this condition, the muscles increasingly lose strength, which can ultimately cause people to end up in a wheelchair.