De Graeff N* & De Proost L (Apr 2025). A multicriterial approach to evaluating the moral (in)equivalence of human embryos and stem cell-derived embryo models. Journal of Medical Ethics.
Blanch-Asensio, A., Grandela, C., Mummery, C.L. et al. STRAIGHT-IN: a platform for rapidly generating panels of genetically modified human pluripotent stem cell lines. Nat Protoc (2024).
Celine M. Roelse, Arend W. Overeem, Yolanda W. Chang, Meriam Boubakri and Susana M. Chuva de Sousa Lopes: Isolation and In Vitro Culture of Germ Cells and Sertoli Cells from Human Fetal Testis. Germ Cell Development (2024)
STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells. Blanch-Asensio A, Grandela C, Brandão KO, de Korte T, Mei H, Ariyurek Y, Yiangou L, Mol MPH, van Meer BJ, Kloet SL, Mummery CL, Davis RP.Cell Rep Methods. 2022 Sep 22;2(10):100300.
Vincent van Batenburg, Susanne C. van den Brink, Marloes Blotenburg, Anna Alemany, Naomi Moris, Peter Baillie-Johnson, Yasmine el Azhar, Katharina F. Sonnen, Alfonso Martinez Arias and Alexander van Oudenaarden*: Generating gastruloids with somite-like structures from mouse embryonic stem cells. Nature Protocol Exchange (2020 Feb 19)
Marek J. Oostrom, Wilke H.M. Meijer and Katharina F. Sonnen*: A microfluidics approach for the functional investigation of signalling oscillations governing somitogenesis. Journal of Visualized Experiments (2021)
Qijing Lei, Xin Lai, Jitske Eliveld, Susana M. Chuva de Sousa Lopes, Ans M.M. van Pelt and Geert Hamer: In Vitro Meiosis of Male Germline Stem Cells. Stem Cell Reports (2020)
Developments in medical technology can raise moral dilemmas. This also applies to stem cell research and specifically to the development of embryo models. Ethical, legal and social issues (ELSI), also known as Socially Responsible Innovation (MVI), are therefore a strong point of attention within the program.
The Dutch Embryo Model Meeting presents a valuable opportunity for scientists involved in research with stem-cell-based embryo models to showcase their work, and many of the researchers involved in our program eagerly anticipate presenting their research findings at this event.
The recent report of the Rathenau Institute, entitled 'Seeds for a Societal Debate', is now online!
In the Netherlands, about two thousand people live with the muscle disease FSHD. With this condition, the muscles increasingly lose strength, which can ultimately cause people to end up in a wheelchair.
